Sergei Stafeev is the author of more than 150 scientific articles published in both Russian and international journals.

His research interests lie in the field of optics of semiconductors, laser sensing, and systems and methods of visualization of optical and electrical inhomogeneities of semiconductors and semimetals.

Some of his research works focus on such pedagogical issues as methods of teaching general physics, modern information technologies in education, and historical aspects of the development of optical concepts.

Sergey Stafeev has developed a lecture course in the field of wave and quantum optics.

He has been coordinating the development of an educational portal within the program "Development of a unified educational environment of Russia", supported by the Ministry of Science and Higher Education of the Russian Federation.

The Deputy Chairman of the Dissertation Council D 212.227.06, the member of the Dissertation Council D 212.227.01.

In 2004, Sergey Stafeev was awarded the medal "In memory of the 300th anniversary of St. Petersburg".

Prof. Stafeev has publications in "Scientific and technical messenger of Information Technologies, Mechanics and Optics".