Valery Khramov has worked at ITMO University as a teaching assistant (1975—1982), Assistant Professor of the Electronics of Quantum Sized Systems Department (1982—1997), Head of the Department of Laser Technologies and Bio-Medicine Optics (since 1997).
In 2003—2005 he was a director of Vavilov State Optical Institute.
Valery Khramov is the author of more than 100 books and articles. His research interests lie in the area of Electronics of Quantum Sized Systems and Laser Technology. He conducts research on solid-state lasers of high brightness precision feature adjustment. He took part in creation of lasers for Space experiment program «Phobos».